Category: Science

WASHINGTON — Airbus Defence and Space is joining a commercial space station project led by Voyager Space, a move that could potentially make it easier for European governments to use the station after the retirement of the International Space Station.

Denver-based Voyager Space announced Jan. 4 a partnership with Airbus on its Starlab commercial space station project. Airbus will provide “technical design support and expertise” for Starlab, the companies said, but did not disclose additional details about the partnership or financial terms.

Voyager Space announced plans for Starlab in October 2021 working with Lockheed Martin. Starlab, as described at the time, would feature in inflatable module, docking node and bus, capable of hosting up to four astronauts at a time.

Voyager Space, through its subsidiary Nanoracks, won one of three NASA Commercial Low Earth Orbit Development, or CLD, awards from NASA in December 2021. The $160 million Space Act Agreement is intended to support design work on Starlab as NASA prepares to transition from the ISS to commercial space stations by the end of the decade.

That transition will also involve NASA’s international partners on the ISS, something that both Airbus and Voyager Space officials alluded to in the announcement of their partnership. “Working with Airbus we will expand Starlab’s ecosystem to serve the European Space Agency (ESA) and its member state space agencies to continue their microgravity research in LEO,” Dylan Taylor, chairman and chief executive of Voyager Space, said in the announcement.

“This collaboration is an important step in making Starlab a reality, providing a foundation for long-lasting European and American leadership in space,” said Jean-Marc Nasr, executive vice president of space systems at Airbus Defence and Space, in the same statement.

ISS partners have pondered how they will make use of commercial space stations run by American companies. Current ISS arrangements, where space agencies barter for services, are unlikely to apply to commercial facilities, where agencies may have to work directly with the station’s operator rather than through NASA.

“We need to find ways to work together, certainly in other ways than we did before,” said Peter Gräf, director of applications and science at the German space agency DLR, during a panel discussion at the AIAA ASCEND conference in October. “There are a lot of options available and the main players are in heavy discussions on that.”

Direct payments from European governments to American companies for use of commercial space stations could be politically problematic. “The taxpayers in Europe don’t want to pay directly to private American companies,” said Nicolas Maubert, space counselor at the French Embassy in the U.S. and representative of the French space agency CNES in the U.S., at the conference panel. Those concerns may be alleviated, though, if companies from Europe and other ISS partners are involved with the stations.

ESA officials, who are beginning work on their post-ISS plans, are aware of those concerns. “Shall we pay directly to commercial providers in the U.S.? We can, of course, but that is euros directly supporting U.S. industry. Is that something Europe wants to do, that our member states want to do?” said Frank De Winne, head of ESA’s European Astronaut Center, in an interview during ESA’s ministerial council meeting in Paris in November.

How ESA will deal with commercial space stations is something the agency will study leading up to its next ministerial council meeting in 2025, but he said one option would be for ESA to fund development of a European crewed vehicle that could service those stations.

“If we talk to the commercial providers today, to the CLDs that are being funded by NASA, they all tell us the same thing: they are interested in transportation,” he said. “For them to keep their costs low on transportation, they want competition. It’s as simple as that.”

Airbus is not the first European company to be involved in a commercial space station project. Thales Alenia Space is building modules for Axiom Space that will initially be installed on the ISS but eventually be detached to form a commercial space station.

Twitter and online news articles show potential for tracking the timing and location of invasive insect spread, a new study shows.

The researchers say these sources are promising for filling in gaps when official data are not widely available.

“The idea was to explore if we could use this data to fill in some of the information gaps about pest spread, and ultimately, to support the development of better predictive models of where pest spread is happening, and when to use costly control measures,” says Laura Tateosian, associate teaching professor in the Center for Geospatial Analytics at North Carolina State University.

“Even though these are not formal scientific sources, we found that we could clearly see some of the major events that were occurring about two invasive pests in the news, and on Twitter.”

In the study, the researchers tracked past tweets about two insects—the spotted lanternfly and Tuta absoluta—compiled by a internet-based subscription service, Brandwatch, as well as online news articles aggregated by Google News and GDELT, or the Global Database of Events, Language, and Tone Project.

The spotted lanternfly, which was first reported in the United States in Pennsylvania in 2014, is an insect native to Asia that can damage or destroy grapes, cherries, hops, certain lumber trees, and other plants. The research team tracked historical posts about spotted lanternfly in Pennsylvania in a single year in 2017, and then globally between 2011 and 2021.

Tuta absoluta, an insect also known as the tomato leaf miner, is native to South America. It was discovered in Spain in 2006, and has spread into parts of Europe, Africa, Asia, and the Middle East. It has been nicknamed the “tomato Ebola” because of the devastation it can cause to tomato crops. The researchers tracked posts about Tuta absoluta between 2011 and 2021.

“While some invasive insects have reached their global range, in both of these cases, the pests are actively spreading,” says Ariel Saffer, a graduate student in geospatial analytics.

“We launched this as a proof-of-concept study to see if it would be scientifically reasonable to use these sources to track pest spread. We compared information in places where the insects were known to be present to see if these sources accurately captured existing knowledge.”

The researchers found that activity on Twitter and in news stories tracked some of the patterns in official surveys. For example, the volume of Twitter posts and news activity about spotted lanternfly tracked the seasonal pest cycle, with more activity in the summer and fall.

In terms of location, they saw a high volume of tweets and news articles in areas located at the epicenter of outbreaks. In Pennsylvania, news articles captured a subset of counties confirmed in 2017 by USDA Animal and Plant Health Inspection Service survey data, but also uncovered one county not listed in official records.

For Tuta absoluta, the team found posts on Twitter and in news stories often coincided with global pest spread, as compared to reports gathered by the European and Mediterranean Plant Protection Organization (EPPO). Information in news and Twitter posts also aligned with survey data for this pest in Nigeria, and sometimes before that information was widely available in scientific sources.

The findings suggest Twitter and news information could be useful to supplement official data sources, but more work is needed, the researchers say.

“News media and social media have the potential to give you more immediate insight into what’s going on, especially if scientific information on insect spread is not immediately published in scientific literature, or not widely available to other scientists,” Saffer says.

“Also, relying on data from scientific publications can sometimes offer a patchwork coverage of space and time, depending on when that study happened. It can be hard to get aggregated information in continuous time, especially at the global scale, as that information can be managed by multiple agencies.”

The study appears in the journal Computers, Environment and Urban Systems.

Source: NC State

A common fatty acid found in the Western diet breaks down into compounds that contribute to increased temperature and pain—but not itch—sensitivity in people with psoriasis lesions, researchers report.

The finding could lead to better understanding of how lipids communicate with sensory neurons, and potentially to improved pain and sensitivity treatments for psoriasis patients.

Linoleic acid is a fatty acid found in vegetable oils, nuts, and seeds, and is one of the predominant fatty acids found in the Western diet. Metabolites from linoleic acid—the products formed when the body breaks it down through digestion—play a role in skin barrier function.

“We noticed high levels of two types of lipids derived from linoleic acid in psoriatic lesions,” says Santosh Mishra, associate professor of neuroscience at North Carolina State University and corresponding author of the research in JID Innovations.

“That led us to wonder whether the lipids might affect how sensory neurons in these lesions communicate. We decided to investigate whether their presence could be related to the temperature or pain hypersensitivity that many psoriasis patients report.”

The research team used mass spectrometry to create lipid profiles of skin from psoriatic lesions. They focused on two types of linoleic acid-derived lipids, or oxylipids: 13-hydroxy-9,10-epoxy octadecenoate (9,13-EHL) and 9,10,13-trihydroxy-octadecenoate (9,10,13-THL). The first form, 9,13-EHL, can convert into the more stable 9,10,13-THL form via interaction with certain enzymes.

The researchers found that while both forms bind to receptors on sensory neurons within the skin, the more stable form—9,10,13-THL—had a longer lasting effect than 9,13-EHL.

They also found that once the lipids bind to the neuronal receptor, they activate the neurons expressing TRPA1 and TRPV1 receptors that are involved in temperature and pain hypersensitivity, opening communications channels to the central nervous system.

Interestingly, the lipids did not have any effect on itch.

“It was surprising that these lipids could create hypersensitivity but not impact itch sensation, which is usually the most troublesome symptom associated with psoriasis,” Mishra says. “This most likely has to do with how the neuron is activated—a mechanism we still haven’t uncovered.”

Now that an association between linoleic acid and hypersensitivity to temperature and pain has been established, the researchers want to further explore exactly how this response is created. They hope that the answers may lead to solutions that can relieve these symptoms in psoriasis patients.

“We know that this lipid moves from one form to another, but don’t yet know what causes that,” Mishra says. “We also know what protein the lipids are binding to, but not where the bond occurs. Answering these questions may hopefully lead to new therapies—or dietary solutions— for some psoriasis sufferers.”

The National Institute on Aging and the National Institutes of Health supported the work.

Source: NC State

Testing for the presence of a single immune system molecule on nasal swabs can help detect stealthy viruses not identified in standard tests, a new study shows.

As the COVID-19 pandemic showed, potentially dangerous new viruses can begin to spread in the population well before the global public health surveillance system can detect them.

“Finding a dangerous new virus is like searching for a needle in a haystack,” says Ellen Foxman, associate professor of laboratory medicine and immunobiology at Yale University and senior author of the study in The Lancet Microbe. “We found a way to significantly reduce the size of the haystack.”

Public health officials typically look to a few sources for warning signs of emerging disease. They study emerging viruses in animals that may transmit the infection to humans.

But determining which of the hundreds, or thousands, of new viral variants represent a true danger is difficult. And they look for outbreaks of unexplained respiratory ailments, which was how SARS-Cov-2, the virus that causes COVID-19, was discovered in China late in 2019.

By the time an outbreak of a novel virus occurs, however, it may be too late to contain its spread.

For the new study, Foxman and her team revisited an observation made in her lab in 2017, which they thought may provide a new way to monitor for unexpected pathogens.

Nasal swabs are commonly taken from patients with suspected respiratory infections and are tested to detect specific signatures of 10 to 15 known viruses. Most tests come back negative.

But as Foxman’s team observed in 2017, in a few cases the swabs of those who tested negative for the “usual suspect” viruses still exhibited signs that antiviral defenses were activated, indicating the presence of a virus. The telltale sign was a high level of a single antiviral protein made by the cells that line the nasal passages.

Based on that finding, the researchers applied comprehensive genetic sequencing methods to old samples containing the protein and, in one sample, found an unexpected influenza virus, called influenza C.

The researchers also used this same strategy of retesting old samples to search for missed cases of COVID-19 during the first two weeks of March 2020. While cases of the virus had surfaced in New York State around that same time, testing was not readily available until weeks later.

Hundreds of nasal swab samples collected from patients at Yale-New Haven Hospital during that time had tested negative for standard signature viruses. When tested for the immune system biomarker, the vast majority of those samples showed no trace of activity of the antiviral defense system. But a few did; among those, the team found four cases of COVID-19 that had gone undiagnosed at the time.

The findings reveal that testing for an antiviral protein made by the body, even if the tests for known respiratory viruses are negative, can help pinpoint which nasal swabs are more likely to contain unexpected viruses.

Specifically, screening for the biomarker can allow researchers to narrow down the search for unexpected pathogens, making it feasible to do surveillance for unexpected viruses using swabs collected during routine patient care.

Samples found to possess the biomarker can be analyzed using more complex genetic testing methods to identify unexpected or emerging pathogens circulating in the patient population and jumpstart a response from the health care community.

Yale’s Nagarjuna R. Cheemarla and Jason Bishai are co-lead authors of the paper, as are former Yale researchers Amelia Hanron and Joseph R. Fauver.

Source: Yale University

Researchers have developed a stretchable strain sensor that has an unprecedented combination of sensitivity and range.

That allows it to detect even minor changes in strain with greater range of motion than previous technologies.

The researchers demonstrated the sensor’s utility by creating new health monitoring and human-machine interface devices.

Strain is a measurement of how much a material deforms from its original length. For example, if you stretched a rubber band to twice its original length, its strain would be 100%.

“And measuring strain is useful in many applications, such as devices that measure blood pressure and technologies that track physical movement,” says Yong Zhu, corresponding author of a paper on the work and professor of mechanical and aerospace engineering at North Carolina State University.

“But to date there’s been a trade-off. Strain sensors that are sensitive—capable of detecting small deformations—cannot be stretched very far. On the other hand, sensors that can be stretched to greater lengths are typically not very sensitive. The new sensor we’ve developed is both sensitive and capable of withstanding significant deformation,” says Zhu.

“An additional feature is that the sensor is highly robust even when over-strained, meaning it is unlikely to break when the applied strain accidentally exceeds the sensing range.”

The new sensor consists of a silver nanowire network embedded in an elastic polymer. The polymer features a pattern of parallel cuts of a uniform depth, alternating from either side of the material: one cut from the left, followed by one from the right, followed by one from the left, and so on.

“This feature—the patterned cuts—is what enables a greater range of deformation without sacrificing sensitivity,” says Shuang Wu, who is first author of the paper and a recent PhD graduate.

The sensor measures strain by measuring changes in electrical resistance. As the material stretches, resistance increases. The cuts in the surface of the sensor are perpendicular to the direction that it is stretched. This does two things. First, the cuts allow the sensor to deform significantly. Because the cuts in the surface pull open, creating a zigzag pattern, the material can withstand substantial deformation without reaching the breaking point. Second, when the cuts pull open, this forces the electrical signal to travel further, traveling up and down the zigzag.

“To demonstrate the sensitivity of the new sensors, we used them to create new wearable blood pressure devices,” Zhu says. “And to demonstrate how far the sensors can be deformed, we created a wearable device for monitoring motion in a person’s back, which has utility for physical therapy.”

“We have also demonstrated a human-machine interface,” Wu says. “Specifically, we used the sensor to create a three-dimensional touch controller that can be used to control a video game.”

“The sensor can be easily incorporated into existing wearable materials such as fabrics and athletic tapes, convenient for practical applications,” Zhu says. “And all of this is just scratching the surface. We think there will be a range of additional applications as we continue working with this technology.”

The paper appears in the journal ACS Applied Materials & Interfaces.

Support for the work came from the National Science Foundation, the National Institutes of Health, and the US Department of Defense.

Source: NC State

A new study with mice finds that proteins made by stem cells that regenerate the cornea may be new targets for treating and preventing injuries.

People with a condition known as dry eye disease are more likely than those with healthy eyes to suffer injuries to their corneas.

Dry eye disease occurs when the eye can’t provide adequate lubrication with natural tears. People with the common disorder use various types of drops to replace missing natural tears and keep the eyes lubricated, but when eyes are dry, the cornea is more susceptible to injury.

“We have drugs, but they only work well in about 10% to 15% of patients,” says senior investigator Rajendra S. Apte, professor in the department of ophthalmology and visual sciences at Washington University in St. Louis.

“In this study involving genes that are key to eye health, we identified potential targets for treatment that appear different in dry eyes than in healthy eyes.

“Tens of millions of people around the world—with an estimated 15 million in the United States alone—endure eye pain and blurred vision as a result of complications and injury associated with dry eye disease, and by targeting these proteins, we may be able to more successfully treat or even prevent those injuries.”

For the study in the Proceedings of the National Academy of Sciences, the researchers analyzed genes expressed by the cornea in several mouse models—not only of dry eye disease, but also of diabetes and other conditions. They found that in mice with dry eye disease, the cornea activated expression of the gene SPARC. They also found that higher levels of SPARC protein were associated with better healing.

“We conducted single-cell RNA sequencing to identify genes important to maintaining the health of the cornea, and we believe that a few of them, particularly SPARC, may provide potential therapeutic targets for treating dry eye disease and corneal injury,” says first author Joseph B. Lin, an MD/PhD student in Apte’s lab.

“These stem cells are important and resilient and a key reason corneal transplantation works so well,” Apte explains. “If the proteins we’ve identified don’t pan out as therapies to activate these cells in people with dry eye syndrome, we may even be able to transplant engineered limbal stem cells to prevent corneal injury in patients with dry eyes.”

The National Eye Institute, the National Institute of Diabetes and Digestive and Kidney Diseases, and the National Institute of General Medical Sciences of the National Institutes of Health supported the work. Additional funding came from the Jeffrey T. Fort Innovation Fund, a Centene Corp. contract for the Washington University-Centene ARCH Personalized Medicine Initiative, and Research to Prevent Blindness.

Source: Washington University in St. Louis

New research reveals an added layer of nuance in our sense of smell.

The delicate fragrance of jasmine is a delight to the senses. The sweet scent is popular in teas, perfumes and potpourri. But take a whiff of the concentrated essential oil, and the pleasant aroma becomes almost cloying.

Part of the flower’s smell actually comes from the compound skatole, a prominent component of fecal odor.

“Consider for instance the smell of a ripe banana from a distance (sweet and fruity) versus up-close (overpowering and artificial).”

Our sense of smell is clearly a complex process; it involves hundreds of different odorant receptors working in concert. The more an odor stimulates a particular neuron, the more electrical signals that neuron sends to the brain.

But the new research reveals that these neurons actually fall silent when an odor rises above a certain threshold. Remarkably, this was integral to how the brain recognized each smell.

“It’s a feature; it’s not a bug,” says Matthieu Louis, an associate professor in the department of molecular, cellular, and developmental biology at the University of California, Santa Barbara.

The paradoxical finding, published in Science Advances, shakes up our understanding of olfaction.

“The same odor can be represented by very different patterns of active olfactory sensory neurons at different concentrations,” Louis says. “This might explain why some odors can be perceived as very different to us at low, medium, and very high concentrations. Consider for instance the smell of a ripe banana from a distance (sweet and fruity) versus up-close (overpowering and artificial).”

Humans have several million sensory neurons in our noses, and each of these has one type of odorant receptor. Altogether, we have about 400 different types of receptors with overlapping sensitivity. Each chemical compound is like a different shoe that the receptor is trying on. Some shoes fit snugly, some fit well, while others don’t fit at all. A better fit produces a stronger response from the receptor. Increasing an odor’s concentration recruits neurons with receptors that have are less sensitive to that substance. Our brain uses the combination of activated neurons to distinguish between odors.

Scientists thought that neurons would effectively max out above certain odor concentrations, at which point their activity would plateau. But the team led by Louis’ graduate student, David Tadres, found the exact opposite: Neurons actually fall silent above a certain level, with the most sensitive ones dropping off first.

Looking at flies

Fruit fly larvae make an ideal model for studying olfaction. They have as many types of odorant receptors as the number of sensory neurons—namely, 21. This one-to-one correspondence makes it simple to test what each neuron is doing.

For the study, Tadres examined larvae with a mutation that entirely eliminated their sense of smell. He then selectively turned that sense back on in a single sensory neuron, enabling the larvae to detect only odors that activated that specific receptor. He placed them next to an odor source and watched.

Even with a single functioning olfactory channel, the larvae could still move toward the stronger smell. But remarkably, they stopped a certain distance away from the source, and just circled it in a fixed orbit. Tadres repeated the experiment with a neuron slightly less sensitive to the odor he was testing, and found that the larvae got closer to the source before stopping.

Puzzled by this behavior, Tadres used electrodes to measure the activity of the sensory neuron. As expected, signaling increased as the odor became more concentrated. But rather than plateau above a certain level, the activity crashed to zero. That’s why the mutant larvae circled the odor source; above a certain concentration, the smell simply disappeared.

“The silencing of the olfactory sensory neuron could easily explain the circling behavior, which was mysterious before,” Tadres says. “From there it wasn’t hard to extrapolate that the current view of how odors are encoded at different concentrations needed to be updated.”

Researchers knew that excessive stimulation can cause nerves to go silent, an effect called “depolarization block.” However, the consensus was that this sort of overload doesn’t occur under natural, healthy conditions. Indeed, this response is associated with issues like epilepsy when it occurs in the central brain. But when Tadres observed it affecting the larvae’s behavior, he suspected that it wasn’t merely an artifact of the experiment.

Digging deeper

Tadres and Louis began investigating the cause of the depolarization block. For assistance, they reached out to Professor Jeff Moehlis, chair of the mechanical engineering department, and Louis’ doctoral student Philip Wong (co-advised by Moehlis), who started constructing a mathematical model of the system.

The voltage across a neuron’s membrane can be described by a system of equations. This model was a breakthrough finding in 1952, and earned a Nobel Prize for its discoverers, Alan Hodgkin and Andrew Huxley. For this case study, Wong added a mathematical representation of the odorant receptor, the “trigger” that initiates the rest of the model. He also included a modification from the field of epilepsy research wherein high stimulation turns off certain ion channels in the cell membrane, preventing a neuron from firing.

Wong’s model was able to fit and predict Tadres’ measurements of the neuron’s electrical activity. “This was quite useful because the electrophysiology data was difficult to collect and very time consuming to analyze,” Wong says.

In addition to corroborating the experimental results, the model is guiding the team as they continue investigating this effect. “This model may tell us exactly how each neuron is responding to different odors,” Wong says.

The model’s success points to a possible source of the depolarization block: a specific ion channel present in neurons across the animal kingdom. If true, this suggests that most sensory neurons might fall silent following strong and sustained stimulation. The team hopes to validate this hypothesis in an upcoming study.

What’s more, the model predicted that the system would behave differently going up from low odor concentrations versus coming down from high concentrations. Measuring the voltage of the larvae’s neurons confirmed this. When going down, the neuron did not reactivate below the threshold where it had fallen silent. In fact, it largely remained silent until the odor concentration came back down to zero before returning to normal activity.

Our complex sense of smell

This study demonstrated that high odor concentrations can silence the most sensitive receptors. This counterintuitive result marks a fundamental shift in our understanding of smell.

“As you increase the concentration of an odor, you’ll start recruiting more and more odorant receptors that aren’t as sensitive to that compound,” Louis explains. “And so, the common view until our work was that you just kept adding active odorant receptors to the picture.”

This makes sense, until you consider the system as a whole. If this were the case, then a compound should activate pretty much all of the receptors above a certain level. “So it would be impossible for you to distinguish between two different odors at very high concentrations,” Tadres says. “And that’s clearly not the case.”

Having certain sensory neurons drop out as others join in might help preserve the distinction between odors at high concentrations. And this could prove important for survival. It might prevent poisons and nutrients that share certain compounds from smelling alike when you take a big whiff of them.

It could also have consequences for how we perceive odors. “We speculate that removing successive high-sensitivity olfactory sensory neurons is like removing the root of a musical chord,” Louis says. “This omission of the root is going to alter the way your brain perceives the chord associated with a set of notes. It’s going to give it a different meaning.”

A subtle floral note suggests an orchard may be in bloom nearby, useful information for a hungry animal. Meanwhile, the same compounds in higher concentrations could produce the pungent ripeness of decaying fruit or even sewage: something best avoided. Studies like this reveal ever more complexities to our sense of smell, which evolved to help us navigate an equally complex chemical landscape.

Source: UC Santa Barbara

A study on the factors driving a rise in weight gain among pregnant woman in Nepal rules out poor diet quality in the first trimester as one of the major causes, say the researchers.

Historically, one of the greatest challenges facing pregnant women in Nepal and other low-income countries was undernourishment, a result of poverty. While that continues to be a concern, doctors are seeing some of the same issues confronting women in western nations: excessive weight gain and the health risks that come with it, such as high blood pressure and gestational diabetes.

Obstacles to addressing the problem included a lack of data, prompting a pilot study on gestational weight gain among pregnant women in Nepal by Shristi Rawal, an assistant professor of nutritional sciences at the Rutgers School of Health Professions; Kelly Martin, a 2021 graduate of the doctor in clinical nutrition program and an assistant professor at the State University of New York College at Oneonta; and other faculty members.

Their findings appear in the journal BMC Nutrition.

Rawal, who is from Nepal, says the impact of diet quality has been studied in wealthier countries, but had not been investigated in the context of many low-income countries, including Nepal.

“Studies on perinatal complications have largely been based on Caucasian samples from high income countries, and there has been a lack of diversity in general in terms of women represented in these studies,” she says. “Pregnancy complications are increasing in Nepal, and no one was doing this work there. This is a first step.”

The study tracked 101 pregnant women receiving prenatal care at Dhulikhel Hospital at Kathmandu University. Rawal and her colleagues administered a 21-item questionnaire to assess intake of foods from groups categorized either as healthy (such as whole grains, fruits, and vegetables) or unhealthy (such as desserts, refined grains, and red meats), to the participants.

The study looked at diet quality in the first trimester and the rate of gestational weight gain from second to the third trimester but found no link between diet quality in early pregnancy and rate of gestational weight gain. It did find that a high intake of red meat could be a potential factor in driving up weight.

“The most striking result is that so many had excessive rate of gestational weight gain,” says Rawal. “If diet quality is not it, it could be daily caloric intake, physical activity, or sleep that could be associated with gestational weight gain. It could be other diet, lifestyle, or clinical factors. The next step is collecting more data and in a larger sample. ”

The pilot study established the need to conduct a larger birth cohort study with hundreds to thousands of women seeking antenatal care at Dhulikhel Hospital.

A key part of the pilot study also was to evaluate the efficacy of a novel dietary screening tool in capturing valid dietary data in the target population of Nepalese pregnant women.

In a paper published in the Maternal and Child Health Journal, the researchers conclude that the 21-question dietary screen tool modified for use by pregnant Nepalese woman is a valid and reliable instrument for assessing the dietary intake of pregnant women in Nepal.

“This adds credence to the tool, and we now know that it has cultural applicability to the setting and that it measures what it is intended to measure,” says Martin, who was the first author of both papers. “This is important for conducting further studies on diet quality in this population.”

Rawal is in the midst of a study testing a mobile app that supports Nepalese women with gestational diabetes by providing them with information and tools to adopt diet and lifestyle modifications needed to self-manage their condition.

Source: Rutgers University

HELSINKI — China is aiming to expand the use of its coastal Wenchang spaceport to both allow a greater overall launch rate and establish new facilities needed for crewed lunar missions.

The Wenchang Satellite Launch Center was completed in 2014 and has since allowed China to launch its new generation kerolox and cryogenic rockets. These have in turn enabled the country to launch interplanetary and lunar missions and construct and supply its Tiangong space station.

Now though the spaceport is being expanded to additionally facilitate commercial launches and the growth of China’s commercial space sector and, eventually, launch a new-generational crew launch vehicle and the super heavy-lift Long March 9 rocket. 

The development is an apparent part of long term plans for China to upgrade its overall space capabilities.

“In the near future, Wenchang will see its launch frequency go from between six to eight times a year, to 20 or 30 times a year,” Zhong Wen’an, chief engineer of the Xichang Satellite Launch Center which oversees Wenchang Satellite Launch Center, told CCTV Dec. 31.

“This is not only a change in quantity but also one in quality. We are also going to add more sites for [the launch of] human moon-landing missions, heavy rockets and commercial ones.” Zhong said.

The crew launcher is expected to have a test launch around 2026, and a pair of the rockets could support a short-term human lunar landing mission before 2030. 

The Long March 9 is planned for use in construction of China’s ILRS lunar base plan and other space infrastructure projects, including space-based solar power plans.

More immediately however, progress on the commercial launch site can be seen from both aerial and satellite imagery. Wenchang has already attracted a number of launch and other space-related companies to establish facilities in the area.

Construction of the Hainan commercial launch centre continues apace. https://t.co/o6Ml8rSBbs

— Andrew Jones (@AJ_FI) December 29, 2022

China has three inland spaceports at Jiuquan in the northwest, Xichang in the southwest and Taiyuan in north China. Jiuquan has recently been expanded to facilitate both launches of commercial solid rockets and new methane-liquid oxygen rockets. 

The country has also begun launching from mobile platforms from the Yellow Sea, supported by infrastructure developed near Haiyang, Shandong province.

Wenchang however has a number of advantages, including the lowest latitude of any of China’s spaceports. It is also accessible by sea, allowing large diameter rocket components to be delivered there. 

China’s inland launch sites are limited in the size of rocket they can launch due to a reliance on the national railway system and its capacities. They also create debris issues downrange due to falling spent rocket stages.

China’s largest rockets, the Long March 5 and 5B, launch from Wenchang. These launch vehicles have allowed China to launch its first interplanetary mission, Tianwen-1, a first lunar sample return mission, and launch the roughly 22-ton modules that make up the Tiangong space station.