On this day in history, Jan. 8, 1790, George Washington delivers first-ever State of the Union address

America’s first president George Washington addressed the assembled Congress with the first State of the Union on this day in history, Jan. 8, 1780.

Washington’s address took place at Federal Hall in New York City — and addressed a variety of topics including national defense, foreign policy, economics and education.

America’s first president started off by congratulating North Carolina for recently joining the federal republic, according to History.com.

ON THIS DAY IN HISTORY, DEC. 4, 1783, WASHINGTON BIDS FAREWELL TO HIS TROOPS AT FRAUNCES TAVERN IN NYC

This decision followed the state’s initial rejection of the Constitution in 1788 for not including a bill of rights.

The official Bill of Rights was eventually written up and dispatched to the 11 out of 13 states that accepted the Constitution before North Carolina’s ratification in 1789.

An illustration of first president George Washington and his cabinet.

An illustration of first president George Washington and his cabinet.
(Library of Congress/Corbis/VCG via Getty Images)

Washington went on to briefly outline his administration’s policies, designed by Alexander Hamilton.

ON THIS DAY IN HISTORY, DEC. 18, 1787, NEW JERSEY BECOMES THIRD STATE TO RATIFY CONSTITUTION, JOINS UNION

As the former commander-in-chief of the Continental Army during the Revolutionary War, Washington was reportedly careful about addressing his support for creating a standing army.

Washington’s idea was controversial, History.com says, but he argued that “providing for the common defense will merit particular regard.”

President George Washington's first cabinet, circa 1790. Left to right: Secretary of War Henry Knox (1750-1806), Secretary of State Thomas Jefferson (1743-1826), Attorney General Edmund Randolph (1753-1813, back turned), Treasury Secretary Alexander Hamilton (175 -1804) and George Washington (1732-1799).

President George Washington’s first cabinet, circa 1790. Left to right: Secretary of War Henry Knox (1750-1806), Secretary of State Thomas Jefferson (1743-1826), Attorney General Edmund Randolph (1753-1813, back turned), Treasury Secretary Alexander Hamilton (175 -1804) and George Washington (1732-1799).
(FPG/Archive Photos/Getty Images)

“To be prepared for war is one of the most effectual means of preserving peace,” Washington said, according to Mountvernon.org.

Washington also encouraged federal influence over certain domestic issues, after discussing federal issues including foreign affairs and national defense in his speech.

ON THIS DAY IN HISTORY, JAN. 6, 1941, FDR DELIVERS FOUR FREEDOMS SPEECH, STEELING AMERICANS FOR WORLD WAR II

The administration at the time, influenced by Hamilton, was looking for more money and some control over sectors such as agriculture, commerce and manufacturing, as well as science and literature, History.com reports.

“Every valuable end of government is best answered by the enlightened confidence of the people.”

Washington said that achieving this would require a federal post office, post roads and a public education system, which he explained would bolster the nation in its new Constitution.

General George Washington resigns his commission on Dec. 23, 1793, in front of Congress in Annapolis. Painting by John Trumbull, circa 1824.

General George Washington resigns his commission on Dec. 23, 1793, in front of Congress in Annapolis. Painting by John Trumbull, circa 1824.
(Universal History Archive/Getty Images)

“Knowledge is in every country the surest basis of public happiness,” the president said in his address. 

“To the security of a free Constitution it contributes in various ways: By convincing those, who are entrusted with the public administration, that every valuable end of government is best answered by the enlightened confidence of the people: And by teaching the people themselves to know and to value their own rights.”

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Washington left his administration with the sentiment that the welfare of the United States is the “great object to which our cares and efforts ought to be directed.”

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The president concluded, “And I shall derive great satisfaction from a cooperation with you, in the pleasing though arduous task of ensuring to our fellow citizens the blessings, which they have a right to expect, from a free, efficient and equal government.”

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Lightning in the 'cataclysmic' Tonga volcano eruption shattered 'all records'



CNN
 — 

When the Hunga Tonga-Hunga Ha’apai volcano erupted in January 2022, it sent shockwaves around the world. Not only did it trigger widespread tsunami waves, but it also belched an enormous amount of climate-warming water vapor into the Earth’s stratosphere.

Now researchers in a new report have unveiled something else: the eruption set off more than 25,500 lightning events in just five minutes. Over the course of just six hours, the volcano triggered nearly 400,000 lightning events. Half of all the lightning in the world was concentrated around this volcano at the eruption’s peak.

The “cataclysmic eruption” shattered “all records,” according to the report from Vaisala, an environmental monitoring company that tracks lightning around the world.

“It’s the most extreme concentration of lightning that we’ve ever detected,” Chris Vagasky, meteorologist and lightning expert at Vaisala, told CNN. “We’ve been detecting lightning for 40 years now, and this is really an extreme event.”

One-minute snapshots of lightning over the Tonga volcano eruption on January 15. The lightning surrounded the volcano "in distinctive ring patterns during the peak of the eruption," Vaisala reports.

The annual report by Vaisala found that 2022 was a year of extremes for lightning. Lightning increased in the US in 2022, with more than 198 million lightning strokes — 4 million more than what was observed in 2021, and 28 million more than 2020.

“We are continuing an upward trend in lightning,” Vagasky said.

The World-Wide Lightning Location Network, another lightning monitoring network led by the University of Washington, which is not involved with the report, said Vaisala’s findings about global lightning as well as the Hunga volcano are consistent with their own observations.

“We can do this because the stronger eruptions generate lightning, and lightning sends detectable radio signals around the world,” Robert Holzworth, the director of the network, told CNN. “The Hunga eruption was absolutely impressive in its lightning activity.”

Researchers have used lightning as a key indicator of the climate crisis, since the phenomenon typically signals warming temperatures. Lightning occurs in energetic storms associated with an unstable atmosphere, requiring relatively warm and moist air, which is why they primarily occur in tropical latitudes and elsewhere during the summer months.

But in 2022, Vaisala’s National Lightning Detection Network found more than 1,100 lightning strokes in Buffalo, New York, during a devastating lake-effect snowstorm that dumped more than 30 inches of snow in the city, but piled historic totals in excess of 6 feet in the surrounding suburbs along Lake Erie. Lake-effect snow occurs when cold air blows over warm lake water, in this case from the Great Lakes. The large difference in temperature can cause extreme instability in the atmosphere and lead to thunderstorm-like lightning even in a snow storm.

More than 1,100 lightning strokes were detected in Buffalo, New York, during a devastating lake-effect snowstorm that dumped more than 30 inches of snow in the city, but piled historic totals in excess of 6 feet in the surrounding suburbs along Lake Erie.

The report noted that many of these lightning events happened near wind turbines south of Buffalo, which Vagasky said was significant. He explained that the ice crystal-filled clouds were lower to the ground than usual, scraping just above the blades of the turbines.

“That can cause what is known as self-initiated upward lightning,” Vagasky said. “So the lightning occurs because you have charged at the tip of this wind turbine blade that is really close to the base of the cloud, and it’s really easy to get a connection of the electric charge.”

This is an area of ongoing research, he said, as the country turns to more clean energy alternatives.

“We’re seeing bigger and bigger wind turbines, and certainly as we’re putting in more and more wind energy and renewable energy, lightning is going to play a role in that,” he said.

The report comes after an unusual year in 2021, when they found lightning strokes increased significantly in the typically frozen Arctic region, which scientists say is a clear sign of how the climate crisis is altering global weather.

“Lightning in polar regions wasn’t mentioned [in this year’s Vaisala report], but our global lightning network shows a trend for much more lightning in the northern polar regions,” Michael McCarthy, research associate professor and associate director of the World Wide Lightning Location Network, told CNN. “That trend closely tracks the observed average temperature changes over the northern hemisphere.

“This close tracking suggests, but does not prove, a climate change effect,” McCarthy added.

Vagasky said lightning in colder areas will only amplify as the planet warms, noting that meteorologists and climatologists have been collecting more data to not only make the climate connections clear but also keep people safe.

“That’s why they’ve named lightning as an essential climate variable,” he said, “because it’s important to know where it’s occurring, how much is occurring, and so you can see how thunderstorms are trending as a result of changing climates.”

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Five dramatic, colorful moments from McCarthy's Speakership fight

Rep. Kevin McCarthy (R-Calif.) was elected Speaker of the House early Saturday morning, after weeks of haggling and a historic 15 roll call votes on the floor.

The lengthy Speakership fight — the first in a century to go past one ballot — played out largely in front of the public, as members repeatedly voted and sometimes negotiated on the floor of the House before C-SPAN’s cameras.

The battle for Speaker, particularly its culmination on Friday night and Saturday morning, produced a number of memorable moments. Here are five of the most dramatic and colorful:

Republicans rush back to Washington

Rep. Kevin McCarthy (R-Calif.) embraces Rep.-elect Wesley Hunt (R-Texas)

Two Republican congressmen — Reps. Ken Buck (R-Colo.) and Wesley Hunt (R-Texas) — rushed back to the Capitol on Friday to vote for McCarthy.

Buck had said he would return for Friday evening votes after being gone during the day for a “non-emergency medical procedure” he had to undergo back in his home state.

But Hunt had to change his plans. He returned home to Texas Friday morning to spend time with his wife and newborn son, who was born prematurely on Monday and spent time in the neonatal intensive care unit.

“Willie needs his father and Emily needs her husband,” Hunt said in a tweet. “Today, I’ll be returning home to hold my son and be at my wife’s side. It’s my intention to get back into the fight as soon as possible.”

Both were McCarthy supporters and McCarthy’s Speaker math meant he needed both of their votes to prevail.

Hunt flew back to Washington later Friday and was in the chamber in time to vote the first time his name was called, while Buck arrived in time to vote when they circled back to his name.

Both received a round of applause from their Republican colleagues.

Lawmaker physically restrained by colleague

Rep. Michael D. Rogers (R-Ala.) is taken away form Reps. Lauren Boebert (R-Colo.) and Matt Gaetz (R-Fla.)

Perhaps the more tense — and chaotic — moment of the night came after McCarthy lost his 14th Speakership vote, one Republicans were confident would be their last.

Rep. Matt Gaetz (R-Fla.) was among the last lawmakers to vote and because only one of the other five holdout Republicans — Rep. Lauren Boebert (R-Colo.) — had changed their vote to “present,” a “present” vote from Gaetz wouldn’t be enough to put McCarthy over the finish. McCarthy needed an affirmative vote from the Florida Republican.

Gaetz voted “present.”

With tensions rising, a heated argument broke out between Gaetz and several McCarthy backers and Rep. Mike Rogers (R-Ala.) appeared to take a step toward Gaetz before he was physically pulled back by Rep. Richard Hudson (R-N.C.), eliciting gasps in the chamber.

Greene gets Trump on the line

As chaos ensued between then 14th and 15th votes, Rep. Marjorie Taylor Greene (R-Ga.) had President Trump on the phone in an effort to whip the final votes for McCarthy.

A widely-circulated photo from Friday night showed Greene holding up her phone to Rep. Matt Rosendale (R-Mont.), one the last six Republican holdouts. Rosendale appeared to refuse the phone call, whose caller ID read “DT.”

Greene later confirmed to The Hill that the phone call was in fact from Trump. 

“It was the perfect phone call,” she added in a post on Twitter, a reference to Trump’s comment about the phone call at the center of his first impeachment.

Trump also reportedly called other Republican holdouts on behalf of McCarthy and McCarthy credited Trump for helping him win the 15th ballot.

Republicans rush to stay in session after McCarthy apparently locks down votes

House Republicans rush to change their vote to adjourn

With Republicans seemingly at an impasse after a 14th failed vote, Rep. Patrick McHenry (R-N.C.) moved to adjourn the House until Monday. 

The motion seemed to have enough GOP support to pass, but then McCarthy and other Republicans rushed to the dais to their change votes and stay in session.

McCarthy had seemingly locked down the votes he needed.

Several Republican lawmakers chanted “one more time” in anticipation of what would be the 15th and final ballot. With all six Republican holdouts changing their vote to “present,” McCarthy was able to secure the Speakership with 216 votes just after midnight on Saturday.  

Democrats troll their Republican colleagues

Rep. Hakeem Jeffries (D-N.Y.)

As Republican infighting continued throughout the week, Democrats watched with a level of amusement, frequently mocking their GOP counterparts.

Several Democratic members brought out buckets of popcorn amid the drawn-out process.

“We are breaking the popcorn out in the Dem Caucus till the Republicans get their act together,” Rep. Ruben Gallego (D-Ariz.) said in a Twitter post on Tuesday, accompanied by a picture of large bucket of popcorn.

Rep. Katie Porter (D-Calif.) was seen during Friday’s votes sitting and reading “The Subtle Art of Not Giving a F—” by Mark Manson.

After McCarthy clinched the Speakership on Saturday morning, House Minority Leader Hakeem Jeffries (D-N.Y.) also appeared to take a jab at the Republican conference, calling it an honor to “finally” welcome members to the 118th Congress.

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How Ram’s 1500 Revolution Compares To Electric Trucks From Ford, Chevy, GMC, Tesla, Rivian And Lordstown

Editor’s Note: This article has been updated with all the latest arrivals in the electric pickup segment including from Ram, Lordstown and GMC

Ram has finally unveiled the first details about its upcoming all-electric, full-size pickup truck with the Ram 1500 Revolution concept, so we can finally compare it to the competition. Set to go into production in 2024, it won’t hit the road until much later than its cross-town rival, the Ford F-150 Lightning, and even the Chevrolet Silverado EV. Today we’re asking, will it be worth the wait?

The last of the Detroit three to throw its hat in the electric pickup ring, the Ram 1500 Revolution has a lot of work to do to make up for its late arrival. The automaker promises, though, that its pickup will be a leader in the “areas customer care about the most: range, towing, payload, and charge time.”

Those qualities should help it compete against not just its cross-town rivals but the new school of all-electric startups like Rivian, Tesla, and Lordstown, all of which want a slice of the apparently quite popular electric pickup pie.


Ram 1500 Revolution

RAM 1500 REVOLUTION SPECS
› 0-60mph N/A
› Estimated 500 miles or range
› Can recover additional 100 miles of range in 10 minutes
› Adjustable air suspension
› Price: Anticipated to start at around $55,000
› Towing Capacity: >10,000 lbs

To start with, let’s look at the new Ram’s stats. Because the vehicle the brand unveiled today is still just a concept that’s set to go into production in more than a year, a variety of details remain unknown. These include the price, how quick it will be, how much power it will put out, and more. We do know, however, that the STLA platform on which it will be based is being designed to deliver more than 500 miles (805 km) of all-electric range, which exceeds that of most of the competition, as you’ll see below.

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Read: 2024 Ram 1500 BEV Previewed By Revolution Concept At CES

Ram promises that it will be able to recover 100 miles of range in just 10 minutes at a 350 kW fast-charging station. And, although it hasn’t revealed any towing figures yet, it has said that it will “lead the competition,” which suggests that it will be able to trailer more than the 10,000 lbs (4,536 kg) that the Chevrolet Silverado and Ford F-150 Lightning can manage, and may even beat the Tesla Cybertruck’s 14,000 lbs (6,350 kg), though it’s unclear if the stainless steel special will even be on roads by 2024. High-tech features like a removable center touchscreen and a movie projector, meanwhile, could help the Ram appeal to more than just contractors.

Prices for the production electric Ram 1500 have not yet been revealed, but it is expected that the automaker will try to keep them in-line with competition like the Ford F-150 Lightning, which now starts at $56,000.


2024 Chevrolet Silverado EV




CHEVROLET SILVERADO EV SPECS
› 0-60mph 4.5 seconds
› Up to 400 miles of range (manufacturer est.)
› Up to 100 miles of range added in 10 minutes of charging
› Independent front and rear suspension
› Price: $39,900 base/$105,000 RST First Edition (before tax credits)
› Towing Capacity: 10,000 lbs

› Payload: 1,300 lbs

Based on GM’s Ultium platform, the Silverado EV is capable of making up to 754 HP (562 kW / 764 PS) and 785 lb-ft which should help it get to 60 mph (96 km/h) in as fast as 4.5 seconds. The truck will also be capable of going up to 400 miles (644 km) on a single charge. Standard DC fast charging, meanwhile, should help it get back to work in a hurry.

Read: 2024 Chevrolet Silverado EV Debuts With 664 HP, 400-Mile Range, And The Avalanche’s Midgate

It will be capable of trailering up to 10,000 lbs (4,536 kg) and can handle up to 1,300 lbs (590 kg) of payload, says Chevy. The Silverado EV will get a work truck variant that, like the Ford F-150 Lightning and the Tesla Cybertruck, was expected to start at around $39,000 when it was announced in early 2022. That price is likely to change before it hit showrooms in fall 2023. Although the Silverado lags behind Ford’s electric pickup, it will have been on the market for a while before the Ram is ready for sale.


2024 GMC Sierra EV


 How Ram’s 1500 Revolution Compares To Electric Trucks From Ford, Chevy, GMC, Tesla, Rivian And Lordstown


GMC SIERRA EV SPECS
› 0-60mph <4.5 seconds
› Driving range of up to 400 miles
› Recharges up to 100 miles in 10 mins (DC fast charge)
› Price: from $50,000 (Estimate from October 2022)
› Towing Capacity: up to 9,500 lbs

Payload: 1,300 lbs

The all-electric version of the GMC Sierra will arrive shortly after the Chevrolet Silverado, in early 2024. The pickup will focus more on a premium experience than it will on capital T truck stuff compared to its competition.

That means a relatively low towing capacity of just 9,500 lbs (4,309 kg) and a payload capacity of 1,300 lbs (590 kg). Available with up to 754 hp (562 kW / 764 PS) and 785 lb-ft (1,063 Nm) of torque in Max Power mode, though, it should be able to hit 60 mph (96 km/h) in less than 4.5 seconds.

With a range of 400 miles (644 km) and DC fast-charging technology, it will be able to regain as many as 100 miles (161 km) of range in just 10 minutes. Thanks to a bidirectional charging system, the truck will also be able to power a home’s essential necessities for up to 21 days, the automaker promises.


2023 Ford F-150 Lightning

FORD F-150 LIGHTNING SPECS
› 0-60mph 4.4 seconds (says Joe Biden)
› 230 miles std range, 300 extended range (EPA est.)
› 41 min to charge to 80 percent
› Independent rear suspension, 14.1-cu ft frunk
› Price: Starting at $56,000
› Towing Capacity: 10,000 lbs (extended range)

Payload: 2,000 lbs

Ford now looks like an early adopter (though it was beaten to the punch by Rivian), but that quick start also means that the F-150 Lightning is slightly behind its Detroit rivals in terms of power. Rated at 563 hp (571 PS/420 kW), and 775 lb-ft (1,051 Nm) of torque, its motors struggle to keep up with the Chevy’s and the GMC’s, which are rated at up to 780 lb-ft (1,058 Nm) and 785 lb-ft (1,063 Nm) of torque, respectively.

Read Also: Who Got It Right, Ford’s Straight-Laced F-150 Lightning Or Tesla’s Cocky Cybertruck?

Despite that, Ford claims that its truck is able to trailer just as much as the Silverado and has a larger payload, which is set at 2,000 lbs (907 kg). Its range, however, tops out at 300 miles, leaving it at something of a disadvantage compared to the competition, especially for those looking to “go further.”


2023 Rivian R1T

RIVIAN R1T SPECS
› 0-60mph 3.2 seconds
› Driving range between 230-400 miles
› Recharges up to 140 miles in 20 mins (DC fast charge)
› Price: from $73,000
› Towing Capacity: up to 11,000 lbs

› Payload: 1,760 lbs

Rivian’s R1T was called a game-changer when it was unveiled, but its $73,000 starting price tag is considerably higher than the competition—though Ford’s prices keep creeping up closer to it. That said, the company is mostly focused on customer trucks, not bare bones work trucks, making the price a little easier to understand.

Despite being the first pickup to the electric party, its stats are still up-to-date. It’s no slouch, with motors that make up to 800 hp (811 PS/596 kW) and 900 lb-ft (1,220 Nm) of torque, and it can to tow up to 11,000 lbs (4,990 kg). Its payload rating, however, is lower than the Ford’s at 1,760 lbs (798 kg).

With a wide variety of lifestyle tricks and an interior designed for comfort, it may appeal to the weekend warriors who are really in the market for a premium pickup. Whether the company can leave a tough 2022 behind it and shine in 2023, though, remains to be seen.


2024 Tesla Cybertruck

TESLA CYBERTRUCK SPECS
› 0-60mph 6.5-2.9 seconds (single motor/tri-motor)
› Range 250-500 miles (single motor/tri-motor, EPA est)
› 44 min to charge to 80 per cent (est)
› Armor glass, 100-cu ft lockable bed with ‘magic’ tonneau
› Price: from $39,900 (claimed)
› Towing Capacity: 7500 lbs std, 14,000 lbs opt

For those who like a gamble, there’s the Tesla Cybertruck. Although it was announced and previewed in 2019, the production version of the vehicle has yet to be unveiled in final production form. The company is still making announcements about the truck, though, including that it will use the same megawatt charging technology as the company’s newly released Semi truck.

With a range between 250 to 500 miles (402-805 km), it should be right up there with the Ram 1500 EV as the longest-distance pickup on sale when it arrives. With up to 690 hp (699 PS/514 kW) and 824 lb-ft (1,117 Nm) of torque, it won’t be the most powerful, but Tesla promises that it will be able to tow up to 14,000 lbs (6,350 kg) and will have 3,350 lbs (1,520 kg) of payload capacity. Despite its outlandish appearance, Tesla has already taken more than 250,000 pre-orders for the futuristic truck.


2023 Lordstown Endurance


 How Ram’s 1500 Revolution Compares To Electric Trucks From Ford, Chevy, GMC, Tesla, Rivian And Lordstown


LORDSTOWN ENDURANCE SPECS
› 0-60mph 6.3 seconds
› Driving range between 200 miles
› Charges from 20 to 80% in 45 minutes
› Price: from $45,000
› Towing Capacity: up to 8,000 lbs

› Payload: 1,050 lbs

And, finally, there’s the underdog Lordstown Endurance. Made by a company that has known no shortage of troubles, the truck’s makers have long believed in its in-hub motor technology to reduce the number of moving parts and give it true all-wheel-drive.

Unfortunately, despite the comeback story (the company has finally started delivering trucks to customers), and its neat technology, the truck’s specs are a little disappointing when compared to the competition. It has about half as much range as many upcoming trucks, less towing capacity, and is slower than the rest, despite making 550 hp (410 kW/558 PS) at peak output.

Although the company’s earning in 2022 were pretty bleak, thanks to materials costs that affected the rest of the industry, too, it did manage to deliver a few trucks in 2022, which puts it ahead of a lot of the trucks above.

So what do you think? Which of the upcoming crop of all-electric pickups will win out, and which will struggle for sales?

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Gene-editing gets fungi to spill secrets to new drugs

A high-efficiency gene-editing tool can get fungi to produce significantly more natural compounds, including some previously unknown to the scientific community, say researchers.

Using the approach that simultaneously modifies multiple sites in fungal genomes, Rice University chemical and biomolecular engineer Xue Sherry Gao and collaborators coax fungi into revealing their best-kept secrets, ramping up the pace of new drug discovery.

It is the first time that the technique, multiplex base-editing (MBE), has been deployed as a tool for mining fungal genomes for medically useful compounds. Compared to single-gene editing, the MBE platform reduces the research timeline by over 80% in equivalent experimental settings, from an estimated three months to roughly two weeks.

Fungi and other organisms produce bioactive small molecules such as penicillin to protect themselves from disease agents. These bioactive natural products (NPs) can be used as drugs or as molecular blueprints for designing new drugs.

The study appears in the Journal of the American Chemical Society.

Gene-editing fungi

Base-editing refers to the use of CRISPR-based tools in order to modify a rung in the spiral ladder of DNA known as a base pair. Previously, gene modifications using base-editing had to be carried out one at a time, making the research process more time-consuming. “We created a new machinery that enables base-editing to work on multiple genomic sites, hence the ‘multiplex,’” Gao says.

Gao and her team first tested the efficacy of their new base-editing platform by targeting genes encoding for pigment in a fungal strain known as Aspergillus nidulans. The effectiveness and precision of MBE-enabled genome edits was readily visible in the changed color displayed by A. nidulans colonies.

‘Cryptic’ genes

“To me, the fungal genome is a treasure,” Gao says, referring to the significant medical potential of fungi-derived compounds. “However, under most circumstances, fungi ‘keep to themselves’ in the laboratory and don’t produce the bioactive small molecules we are looking for. In other words, the majority of genes or biosynthetic gene clusters of interest to us are ‘cryptic,’ meaning they do not express their full biosynthetic potential.

“The genetic, epigenetic, and environmental factors that instruct organisms to produce these medically useful compounds are extremely complicated in fungi,” Gao says. Enabled by the MBE platform, her team can easily delete several of the regulatory genes that restrict the production of bioactive small molecules. “We can observe the synergistic effects of eliminating those factors that make the biosynthetic machinery silent,” she says.

Disinhibited, the engineered fungal strains produce more bioactive molecules, each with their own distinct chemical profiles. Five of the 30 NPs generated in one assay were new, never-before-reported compounds.

“These compounds could be useful antibiotics or anticancer drugs,” Gao says. “We are in the process of figuring out what the biological functions of these compounds are and we are collaborating with groups in the Baylor College of Medicine on pharmacological small-molecule drug discovery.”

Gao’s research plumbs fungal genomes in search of gene clusters that synthesize NPs. “Approximately 50% of clinical drugs approved by the US Food and Drug Administration are NPs or NP-derivatives,” and fungi-derived NPs “are an essential pharmaceutical source,” she says. Penicillin, lovastatin, and cyclosporine are some examples of drugs derived from fungal NPs.

The National Institutes of Health and the Robert A. Welch Foundation supported the research.

Source: Rice University

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IRS targeted poorest taxpayers while millionaires went mostly unscathed in 2022: report

A study of 2022 IRS tax audit data found that a taxpayer in the lowest income bracket is five times more likely to face an audit that would a member of the highest income bracket. 

“The IRS correspondence audit process is structured to expend the least amount of resources to conduct the largest number of examinations – resulting in the lowest level of customer service to taxpayers having the greatest need for assistance,” National Taxpayer Advocate Erin M. Collins said of the report during an annual report to Congress. 

The Transactional Records Access Clearinghouse (TRAC) at Syracuse University examines internal IRS management reports each month, and the group noticed different trends by reviewing 2022 data. Most notably, the group looked at audits, particularly considering the agency relying more heavily on automatically produced letters sent to taxpayers. 

The data showed that the IRS conducted 85% of its audits through these letters, which request additional information and documentation related to specific items of interest. Overall audits dropped from 659,003 in FY 2021 to 626,204 in FY 2022 out of 164 million income tax returns filed last year. 

RELEASED TRUMP TAX RETURNS SHOW PAYMENTS RANGED FROM ALMOST $1 MILLION TO NOTHING

The rate of income tax audits for those in the lowest income bracket hit 12.7 per 1,000, compared to 2.3 per 1,000 among theose in the highest – a nearly five-fold increase. The odds of a millionaire facing an audit were around 1.1%.

The exterior of the Internal Revenue Service (IRS) building in Washington D.C. 

The exterior of the Internal Revenue Service (IRS) building in Washington D.C. 
(AP Photo/Susan Walsh, File)

This roughly matched similar numbers – 13 per 1,000, and 2.6 per 1,000, respectively – during FY 2021, but that rate nearly doubled from FY 2020, when the lowest income bracket saw 7.9 audits per 1,000. 

IRS DELAYS IMPLEMENTING $600 REPORTING THRESHOLD CHANGE ON PAYMENT SERVICES

The TRAC report claimed that the lack of attention toward millionaires resulted from “severe budget cutbacks over the years” that forced the IRS to shift its focus to “easy marks in an era when IRS increasingly relies upon correspondence audits yet doesn’t have the resources to assist taxpayers or answer their questions.” 

COVID-19 USA Economic Stimulus Checks.

COVID-19 USA Economic Stimulus Checks.
(iStock)

A White House spokesperson told Fox News Digital that “President Biden’s Inflation Reduction Act, which is only beginning to build enforcement for wealthy Americans, will finally force wealthy tax cheats to pay their fair share while making it easier for working Americans to get their tax refunds.”

REP. BRADY WARNS SUPREME COURT COULD BE SUBJECT TO TRUMP TAX RETURN PRECEDENT

The spokesperson also blamed Republicans for attacking IRS funding “for years” and claimed that millionaire tax cheats account for $163 billion in tax evasion per year. 

Hollywood stars, including Shakira, Teresa and Joe Giudice and Mike 'The Situation,' have been accused of tax evasion.

Hollywood stars, including Shakira, Teresa and Joe Giudice and Mike ‘The Situation,’ have been accused of tax evasion.
(Getty Images)

The U.S Treasury and Speaker of the House Kevin McCarthy, R-Calif., did not respond to a Fox News Digital request for comment as of the time of publication. 

CLICK HERE TO GET THE FOX NEWS APP

The Inflation Reduction Act provides the IRS with $80 billion in future funding to ramp up its audits and potentially target the wealthiest taxpayers.

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Panic from MSNBC analyst over Republicans investigating federal agencies: ‘The insurrection platform’

MSNBC analyst and former U.S. Congressman from Florida David Jolly lamented the fact that a new select committee in the GOP-majority House might cut big government down to size. 

In response to a tweet from Congressman Dan Bishop, R-N.C. which expressed his hope that a new “Church-style committee” will curb “the weaponization of the federal government,” Jolly complained that the committee will “attack and shred” the government.

Just hours before House Republicans finally voted to elect Kevin McCarthy, R-Calif., as Speaker of the House, Bishop tweeted that he was pleased with new rules negotiated between members and the incoming Speaker that will allow a new House committee to directly challenge federal government overreach.

REPUBLICANS TORCHED FOR MCCARTHY-HOUSE SPEAKER VOTE FIASCO: ‘WORST GAME OF CHICKEN EVER’

LOS ANGELES, CA - OCTOBER 20:  David Jolly speaks onstage at Politicon 2018 at Los Angeles Convention Center on October 20, 2018 in Los Angeles, California.  (Photo by Michael S. Schwartz/Getty Images)

LOS ANGELES, CA – OCTOBER 20:  David Jolly speaks onstage at Politicon 2018 at Los Angeles Convention Center on October 20, 2018 in Los Angeles, California.  (Photo by Michael S. Schwartz/Getty Images)
(Michael S. Schwartz/Getty)

The Republican lawmaker wrote, “With the rules agreement we negotiated, we will have a powerful Church-style committee to go after the weaponization of the federal government – the FBI, DOJ, DHS, and all the rest.”

He also expressed his feeling that the negotiations were a “victory for the constitutional rights of all Americans,” and added, “I’m ready to get to work.”

Bishop’s reference to a “Church-style committee” harkens back to a Watergate era U.S. Senate committee chaired by Sen. Frank Church, D-Idaho. According to Senate.gov, in 1973 that committee’s investigations revealed that the “executive branch had directed national intelligence agencies to carry out constitutionally questionable domestic security operations.”

Jolly, who left Congress and became an independent in 2018, has turned increasingly liberal since becoming an analyst on MSNBC. He balked at Bishop’s notion. 

KEVIN MCCARTHY DELIVERS FIRST REMARKS AFTER WINNING HOUSE SPEAKER: ‘OUR NATION IS WORTH FIGHTING FOR’

In effect, he denied that the current government has engaged in such questionable antics and should be reined in.

Rep. Dan Bishop joins the hosts of "Morning Joe" on Thursday. 

Rep. Dan Bishop joins the hosts of “Morning Joe” on Thursday. 
(Screenshot/MSNBC/MorningJoe)

He forcefully rebutted Bishop’s tweet, saying, “With all the focus on the House rules being given away to the Freedom Caucus et al, this development below may be the most consequential – a new House Committee to attack and shred the federal government.”

Jolly added that the new committee will end up “undermining confidence for millions of Americans in our self governance.”

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One user responded to Jolly’s tweet, proposing the idea that Democrat lawmakers may have some use for such a committee. They wrote, “Could be a farce for sure but the GOP better be careful because my guess is that DEMS will indeed participate in this select committee (unless McCarthy kicks them off).  And, there are some questions I want [FBI director] Wray to answer.”

Though the lawmaker completely trashed that idea, responding, “I think it’s going to serve as their insurrection platform.”

House Speaker Kevin McCarthy, R-Calif., celebrates after taking the oath of office in Washington, D.C., on Jan. 7, 2022.

House Speaker Kevin McCarthy, R-Calif., celebrates after taking the oath of office in Washington, D.C., on Jan. 7, 2022.
(Nathan Posner/Anadolu Agency via Getty Images)

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What happened to Rudy Giuliani? Two classic films help explain it

Editor’s Note: John Marks is the showrunner of “Giuliani: What Happened To America’s Mayor?” A former 60 Minutes producer and US News & World Report correspondent, Marks has worked most recently as a staff showrunner and director at Left/Right, a New York based production house, for a variety of cable and streaming networks. The views expressed in this commentary are his. Read more opinion on CNN. Watch “Giuliani: What Happened to America’s Mayor?” on CNN Sunday at 9 and 10 PM ET/PT.



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My father, a lawyer, once told me he hated movies about the law. With one exception, they were always false in one way or another. Yet the exception spoke to him profoundly, to his years as a defense attorney in the civil courts of Texas. That was 1982’s “The Verdict,” starring Paul Newman, directed by Sidney Lumet with a screenplay by the playwright David Mamet. Newman plays an alcoholic ambulance chaser named Frank Galvin, who finds himself suddenly giving a damn about justice in the midst of a case that should have been open and shut.

John Marks

“The Verdict” is a movie about redemption. Newman’s closing argument is a confession about his own loss of faith in the law. Framed in a wide shot that shows the lawyer, the jury, the judge, the grain of the wood of the court itself, the symbolism of American justice becomes visible.

That image came back to me so many times over the last year and a half as I worked on a CNN documentary series about another lawyer – former US Attorney, former New York Mayor and former counsel to President Donald Trump, Rudolph Giuliani. I thought about Giuliani, and then I thought of this scene and what it meant to my father.

We tend to think of Giuliani in his capacity as mayor, as indicated in the subtitle of the series, “What Happened To America’s Mayor?” – but for most of his life in government and in private practice, the mayor was a lawyer, at one time, by all accounts, a great one. He started there, and it seems likely he will end there. At this time, his law license has been suspended in New York and Washington DC.

Read through this lens, can the story of Giuliani be seen as the tale of a lawyer who lost faith with the law, like the character in “The Verdict,” but without the Hollywood ending? When we ask what happened to him, how one of the most admired (and among some, feared) leaders in modern American history became a target of federal, state and professional investigations, is that the answer?

In the last few weeks of 2022 alone, Giuliani generated one more tumbling wave of negative publicity. He was up before the DC Bar and under investigation by a grand jury in Georgia for trying to overturn an election. When the House January 6 committee referred Trump to the Justice Department for potential prosecution, Giuliani and five other Trump allies were named as potential co-conspirators. After the release of the executive summary of the committee’s final report, a spokesman for Giuliani denied in a statement to CNN aspects of how the report depicted Giuliani, describing him as “an honest, good American who has dedicated his life to serving others and doing the right thing.”

These post-January 6 headlines don’t tell a story of redemption, far from it, but they do punctuate a very different set of headlines far back in Giuliani’s past – reminders of that moment, 20 years ago, when in the face of unprecedented tragedy, he revealed an astounding capacity for leadership that surprised even his harshest critics.

On September 11, 2001, after two terms as a wildly successful, divisive and often self-destructive mayor, Giuliani was recast in a single day as a hero and emerged for a single moment as the most compelling leader in the United States. If that’s not a Hollywood ending, I don’t know what is. Had the story ended there, as political strategist Rick Wilson says in the documentary, schools would have been named after Giuliani.

In the moral economy of public life, does the earlier moment redeem or somehow balance the latter? Certainly, as we found in interviews for the documentary, there are old friends and allies who remain in awe of Giuliani’s behavior in those weeks, loyal to that man and his memory. Others always considered 9/11 the aberration and see 1/6 as a reversion to form.

Early on, Giuliani had a sense of civic duty. His Catholic upbringing in Brooklyn gave him a moral compass, and his Jesuit education gave him a sense of intellectual engagement and responsibility. He had a certain native ferocity that struck a familiar chord in a lot of New Yorkers.

As a young prosecutor, rooting out police corruption, as US Attorney for the Southern District, busting the mob and perp-walking white collar criminals, and as the law-and-order mayor, Giuliani displayed a fearless and often abrasive sense of moral rectitude. If he believed a thing, he implied at his press conferences, it must be right.

At his thorniest, in the New York era, especially in the wake of the police killings of Amadou Diallo and Patrick Dorismond, that sense of narcissistic rectitude could make Giuliani sound like a heartless bully with a racist bent or at the very least a political opportunist who would dog-whistle at racism as soon as the political moment required it. Certainly, many Black New Yorkers saw him that way.

In his finest hour, on the other hand, in the aftermath of the 9/11 attacks, Giuliani’s rectitude was softened by a sense of overwhelming tragedy. More than his actions, his demeanor seemed to reinvent him as a rare thing on the American stage, a wholly noble figure above and beyond politics.

Yet the dark side of power, so evident in Giuliani’s post-Trump behavior, always gripped the former mayor’s imagination – as another, very different movie about law and order suggests. Giuliani’s favorite film for years was Francis Ford Coppola’s mafia epic “The Godfather.” In the documentary, GOP pollster and political consultant Frank Luntz talks about watching it with Giuliani in a basement room of City Hall known as “The Lair.”

“He sits behind me,” Luntz recalled, “and during the entire movie he explains why the life of politics is the life of the Godfather. And, of course, in the one story where Sonny explains to the Godfather that they should be selling drugs, and you see this battle within the family, Rudy starts tapping me on the shoulder, saying, ‘Do you see, do you see? When you have a disagreement, you keep it in the family.’”

A lot of people love that movie, but few end up looking like a key architect of the most serious sedition case in modern American history. Connecting the dots between these educational screenings of “The Godfather” and January 6, one could imagine a vision of the law that makes it solely the tool of whoever wields power, sort of the opposite of the vision in “The Verdict.”

When Newman’s character makes his closing argument before the court, speaking the lines written by David Mamet, he speaks as someone who has rediscovered the law as salvation, and diagnoses the failure that has brought him to this point. “We think of ourselves as victims, and we become victims. We become…we become weak. We doubt ourselves, we doubt our beliefs. We doubt our institutions. And we doubt the law.” And then he proposes the solution: “In my religion, they say, “Act as if ye had faith, and faith will be given to you.” If…if we are to have faith in justice, we need only to believe in ourselves. And act with justice. See, I believe there is justice in our hearts.”

That scene is the law, my father said, explaining his regard for the movie. The essence of it: the advocate, the people, the process by which the rule of law unfolds.

Giuliani’s story is not a movie, of course. It’s real life, and no life, extraordinary or otherwise, is easy to measure from the outside. We cannot know what lies in his heart. Yet there is a clear chasm between the Giuliani of September 11, 2001, and the man of January 6, 2021. In the winter of 2023, it is hard to see anything like a Hollywood ending, public or private, on the horizon. It is hard to detect in the latest headlines about this lawyer an opening of redemptive light that might pave the way.

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