Experimental drug gets rats to eat less

A new drug may offer steady weight loss without common, unwanted side-effects, research in lab animals shows.

The experimental anti-obesity drug could decrease appetite and normalize blood glucose levels.

The drug, delivered by injection, works without causing nausea and vomiting, which are frequent side effects of current weight-loss and diabetes drugs.

The new peptide treatment not only reduces food consumption but also increases the burn rate of calories, causing significant and consistent weight loss in laboratory animals, says Robert Doyle, professor of chemistry at Syracuse University and associate professor of pharmacology at SUNY Upstate Medical University.

Gastric bypass and related procedures cause a reboot of the endocrine system, resulting in weight loss, but surgery is not suitable or available for all who could benefit from it.

“With this new drug treatment, we aim to chemically replicate the benefits of surgery without patients having to undergo surgery,” Doyle says.

Current anti-obesity drugs don’t reliably achieve long-term weight loss for all patients and often cause significant side effects, and many patients must stop taking them (about 70% within two years).

“With other drugs, patients often have to limit the amount they can take because they cannot tolerate more,” says Doyle. “There is a need for a drug that will work for everybody and guarantee a steady, uniform minimum level of weight loss. This new treatment, which could be injected in humans once a week, would be a way to lose a given percent of your weight and not feel sick while doing it.”

The researchers created the peptide drug GEP44 in the laboratory, comprising 44 amino acids that target three different weight-loss and glucoregulatory receptor pathways at the same time.

The drug caused obese rats to eat up to 80% less than they would typically eat. By the end of one 16-day study, they lost an average of 12% of their weight. The drug did not induce vomiting in shrews, a mammalian model that—unlike rats—is capable of vomiting.

The researchers have filed for patents and plan to test the compound in primates.

Doyle and co-principal investigator Christian Roth of Seattle Children’s Research Institute presented their results at the spring meeting of the American Chemical Society (ACS) in March.

The Congressionally Directed Medical Research Programs of the US Department of Defense funded the work.

Source: Syracuse University

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Raptors' Chris Boucher reveals the disgusting message a salty fan sent after losing parlay bet

The growth of legal online sports betting has made fans feel more connected to the athletes. But sometimes the players can be negatively impacted by the people who are gambling on the games they are playing.

Toronto Raptors forward Chris Boucher is the latest professional athlete to endure the ire of a salty fan. 

During an interview with Yahoo Sports Canada, Boucher recalled a time when received a disgusting message after a fan lost a parlay.

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Chris Boucher #25 of the Toronto Raptors warms up ahead of their NBA game against the Minnesota Timberwolves at Scotiabank Arena on March 18, 2023 in Toronto, Canada.

Chris Boucher #25 of the Toronto Raptors warms up ahead of their NBA game against the Minnesota Timberwolves at Scotiabank Arena on March 18, 2023 in Toronto, Canada. (Photo by Cole Burston/Getty Images)

“The betting is not going to make it better now, with the parlays and all that… Somebody said, ‘I chose the wrong slave today.’ Literally sent me that message… Cause I only had 5 points and he needed me to score 10,” Boucher said.

TIMBERWOLVES’ RUDY GOBERT FINED $25K AFTER ACCUSING REFEREES OF MAKING CALLS TO HELP OTHER TEAMS

Boucher or any other player should certainly not be subjected to those types of messages. As more states legalize sports betting, more fans will likely engage in legal online gambling.

Chris Boucher #25 of the Toronto Raptors scores on a first half slam dunk against the Denver Nuggets at Ball Arena on March 6, 2023 in Denver, Colorado.

Chris Boucher #25 of the Toronto Raptors scores on a first half slam dunk against the Denver Nuggets at Ball Arena on March 6, 2023 in Denver, Colorado. (Photo by Dustin Bradford/Getty Images)

Many bettors use sports gambling to simply have fun, but messages like the one Boucher got certainly have negative impact.

Boucher went on to explain how the hateful message impacted his playing experience.

“The players now they don’t really fans as much. We’re lucky we in Toronto and we’ve got the best fans. Imagine if you get messages like this now you don’t really…. know if that person is really talking to you. ‘I need you to score 10 today.’ Do I really want to talk to you now?… If I score 8 you’re gonna flame my Twitter, my Instagram, my everything,” Boucher noted.

Sports betting is becoming a part of daily sports conversation. Virtually every scoreboard is accompanied by some form of betting odds. However, with the access social media provides, some fans seem to be under the impression that they can say almost anything to athletes.

Chris Boucher #25 of the Toronto Raptors looks on during the game against the Philadelphia 76ers on March 31, 2023 at the Wells Fargo Center in Philadelphia, Pennsylvania.

Chris Boucher #25 of the Toronto Raptors looks on during the game against the Philadelphia 76ers on March 31, 2023 at the Wells Fargo Center in Philadelphia, Pennsylvania. (Photo by David Dow/NBAE via Getty Images)

On the court, Boucher and the Raptors are fighting for a playoff spot. Toronto is 38-39 and currently sit in the No. 9 spot in the Eastern Conference standings.

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The Raptors will likely have to compete in the NBA’s play-in tournament, which begins on April 11.

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'I'd have this as my last meal on Earth': Eva Longoria

Editor’s Note: The CNN Original Series “Eva Longoria: Searching for Mexico” journeys across the country’s vibrant regions to reveal its colorful cuisines. The series airs at 9 p.m. ET/PT Sundays.



CNN
 — 

Eva Longoria can’t get enough of this salty dish.

While visiting the sun-soaked city of Mérida on Mexico’s Yucatán Peninsula, she met Regina Escalante, who runs the wildly popular restaurant Merci, and sampled the chef’s grilled fish with sour orange, prepared beachside for flavorful tacos.

In her cooking, Escalante uses one of the region’s most beloved ingredients — salt.

It comes from the fishing village of Celestún, where salt flats produce many forms of the mineral, including the purest, flor de sal. The briny seawater combines with warm rain, slowly evaporating in the tropical heat, and it leaves behind this prized pinkish crystal.

To showcase the flaky salt, Escalante made Longoria grilled sea bass served with avocado and grilled mango in an episode of the CNN Original Series “Eva Longoria: Searching for Mexico.” The fish is stuffed with garlic, rosemary, thyme, sour orange and, of course, a generous dose of salt.

To ramp up the flavor, the chef turned to her secret weapon: an herb brush.

Escalante made the brush by bundling fresh parsley, rosemary and thyme together and used it to lather the fish with a garlic puree made with juice from sour oranges.

“This is my idea of food heaven. Truly, I’d have this as my last meal on Earth,” Longoria said in the docuseries while enjoying the beachside dish.

“The contrast of the crunchy salt and the soft, sweet fish is just sublime.”

Escalante has a simple formula. “With delicious ingredients, we can make delicious recipes,” she said.

"You don't understand how excited I am to finally eat fish on a beach in the Yucatán," Eva Longoria said in "Searching for Mexico." Escalante picked a simple recipe so Longoria could really appreciate the flavor and quality of the local salt.

Chef Regina Escalante prepares this flavorful fish for tacos that are layered with fresh avocado, grilled mango and onion pickled in sour orange juice. She uses Yucatecan flor de sal, but you can use a more readily available substitute, such as coarse Himalayan pink sea salt or gray sea salt.

Makes 4 servings

Ingredients

1 white onion

1 garlic bulb (2 ounces or 60 grams) left whole for roasting plus cloves from ½ garlic bulb (1 ounce or 30 grams), separated, peeled and crushed for stuffing the fish

Scant 1½ cups | 335 milliliters olive oil, divided

3⅓ to 4½ pounds | 1.5-2 kilograms whole fish, such as sea bass, branzino or red snapper

1.8 ounces | 50 grams fresh thyme sprigs, divided

1.8 ounces | 50 grams fresh rosemary sprigs, divided

1.8 ounces | 50 grams fresh flat-leaf parsley sprigs, divided

7 sour oranges (also known as bitter or Seville oranges)

2½ teaspoons | 10 grams coarse Himalayan pink sea salt or gray sea salt, plus more to taste

½ teaspoon (or 2⅓ grams) freshly ground black pepper plus more to taste

1 medium red onion, sliced (7 ounces or 200 grams)

2 mangoes

4 key limes

3.5 ounces | 100 grams fresh cilantro leaves, divided

2 avocados

12 corn tortillas

Instructions

1. Light the grill. When the grill is hot, halve the white onion. Stick 1 onion half on the end of a grilling fork (reserve the other half for another use) and scrub the grates, cut side down, to clean them. Trim about ½ inch (or 1¼ centimeters) off the top of 1 whole garlic bulb, exposing the individual cloves. Drizzle 1 tablespoon (or 15 milliliters) olive oil over and then wrap the bulb in aluminum foil. Roast the garlic bulb over indirect heat until soft, about 40 minutes.

2. When the garlic is nearly halfway through roasting, clean and scale the fish, and let stand at room temperature for 20 minutes.

3. Remove the roasted garlic bulb from the grill and let cool. While it cools, make a bouquet with half of the thyme, rosemary and parsley and secure it with kitchen twine.

4. Stuff the fish with 2 slices from 1 sour orange (reserve the remaining sour orange for another use), crushed cloves from the remaining half of a raw garlic bulb, and the remaining thyme, rosemary and parsley. Sprinkle 1 teaspoon (or 4 grams) salt inside the cavity.

5. Squeeze the cloves out of the roasted garlic bulb into a bowl with a scant 1 cup (or 200 milliliters) oil, 1 teaspoon (or 4 grams) salt and ½ teaspoon (or 2⅓ grams) pepper and mash with a wooden spoon to combine. Squeeze the juice from 3 sour oranges (about 1 cup or 237 milliliters) and mix together.

6. Season fish with salt, place on grill over moderately high heat and drizzle with 4 tablespoons (or 60 milliliters) olive oil. Grill, using the herb bouquet to brush the fish constantly with the garlic puree, until golden and crispy, about 10 minutes on each side (depending on the type and size of fish).

7. Transfer the grilled fish to a serving platter. Let stand for 10 minutes.

The secret weapon to this dish is an herb brush of parsley, rosemary and thyme that's used to apply the garlic puree to the fish.

For the toppings

1. Meanwhile, combine the red onion and juice from 3 sour oranges in a bowl. Let stand for about 10 minutes.

2. Slice each mango lengthwise for a total of 4 skin-on, flat pieces. Taking care not to pierce the skin so it remains attached, score the flesh in a ½-inch (or 1¼-centimeter) crosshatch pattern. Grill the mango slices over medium heat until charred, 3 to 4 minutes. Using tongs, remove from grill and let cool. For each slice, invert the skin and slice it off; transfer the mango cubes to a bowl.

3. Combine mangoes with zest and juice from 1 lime, half of the cilantro, remaining ¼ cup (60 milliliters) olive oil and ½ teaspoon (or 2 grams) salt.

4. In a separate bowl, mash the avocados and season with juice of 1 lime, salt and pepper to taste.

5. Sprinkle the tortillas with water and place them on the grill over indirect heat until the bottom of each is browned in spots, about 45 seconds. Flip with tongs and heat the other side, about 45 seconds.

6. Build the tacos by filling each tortilla first with avocado, then layer the fish, onion and mango. Sprinkle with remaining cilantro and finish with salt. Serve with wedges cut from the remaining 2 limes.

Craving more? Sign up for CNN Travel’s Unlocking Mexico newsletter series. The four-part guide curates the choices in a country with a rich cultural heritage to give you a taste of the superlatives. ¿Quieres leer esta serie en español? Suscríbete aquí.

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Spain's PM Sanchez urges Xi Jinping to communicate with Zelenskyy amid war in Ukraine

Spanish Prime Minister Pedro Sanchez has encouraged Chinese President Xi Jinping to consider Ukraine’s proposal to end the Russian invasion of its country.

Sanchez said at a Beijing press conference on Friday that he notified Xi that Spain supported Ukrainian President Volodymyr Zelenskyy’s proposals to end the war. The recent demands included a request for Russia to restore Ukrainian territory that was taken during and after the annexation of Crimea in 2014.

“I believe it’s a plan that lays the foundations for a durable peace in Ukraine and is perfectly aligned with the United Nations charter and its principles, which have been violated by (Russian President Vladimir) Putin with his invasion,” Sanchez said.

“I transmitted our concern over the illegal invasion of Ukraine,” the prime minister added, saying that he encouraged Xi to talk with Zelenskyy one-on-one.

FOX NEWS POLL: HALF SAY US SHOULD SUPPORT UKRAINE AS LONG AS IT TAKES

Chinese President Xi Jinping meets with Spanish Prime Minister Pedro Sanchez in Bali, Indonesia, Nov. 15, 2022. 

Chinese President Xi Jinping meets with Spanish Prime Minister Pedro Sanchez in Bali, Indonesia, Nov. 15, 2022. 

Sanchez’s comments come after Beijing released its own take on an ideal political solution to the war in Ukraine. However, China’s position paper did not acknowledge that Russia was the aggressor.

Sanchez did commend that China’s paper respected territorial integrity and “its complete and categorical rejection of not only the use but even the threat to use nuclear weapons.”

Xi recently expressed a desire to end the “Cold War mentality” in geopolitics and “extreme” sanctions, but did not call out Russia.

PRESIDENT BIDEN MAKES SURPRISE VISIT TO KYIV, UKRAINE, MEETS WITH PRESIDENT ZELENSKYY

Russian President Vladimir Putin and Chinese President Xi Jinping shake hands in Moscow, Russia, on Tuesday, March 21. 

Russian President Vladimir Putin and Chinese President Xi Jinping shake hands in Moscow, Russia, on Tuesday, March 21.  (Mikhail Tereshchenko/Sputnik/Kremlin Pool Photo)

“We hope that all parties concerned will build a balanced, effective and sustainable European security architecture through dialogue and consultation,” Xi said, according to CCTV.

Last week, Biden said that Russia and China’s economic relationship is ‘vastly exaggerated[d]’ in response to Xi and Putin’s meeting in March to discuss their economic partnership.

Ukrainian President Volodymyr Zelenskyy addresses a media conference after the EU-Ukraine summit in Kyiv, Ukraine, Friday, Feb. 3, 2023. 

Ukrainian President Volodymyr Zelenskyy addresses a media conference after the EU-Ukraine summit in Kyiv, Ukraine, Friday, Feb. 3, 2023.  (AP Photo/Efrem Lukatsky)

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“We hope that the strategic partnership between China and Russia will on the one hand uphold international fairness and justice, and on the other hand promote the common prosperity and development of our countries,” Xi said during a joint press conference.

Reuters contributed to this report.

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Climate activists dye Spanish Steps fountain water black



CNN
 — 

A group called Ultima Generazione or Last Generation have poured what they described as a charcoal-based black liquid into the water of the Barcaccia fountain at the base of the Spanish Steps in central Rome.

The group posted a video on Twitter, showing three men and a woman inside the fountain opening paper bags of a black powder.

“It is absurd that this gesture should shock you, when we are experiencing a drought emergency that is putting agriculture, energy production in crisis,” the group said in the tweet.

A police officer enters the fountain to remove an environmental activist.

The group was stopped by Carabinieri officials and Rome Capital police on Saturday, a police spokesperson said.

They are in custody pending charges of defacing a public monument and entering a fountain.

The water remained black with visible stains to the marble fountain on Saturday afternoon.

Rome’s mayor Roberto Gualtieri visited the fountain – designed by Pietro Bernini in 1629 – and posted a photo of himself staring at the inky water.

“Rome is at the forefront in the fight against climate change and in the protection of the artistic heritage,” he said.

“Throwing black liquid into the Barcaccia, risking ruining it, is an absolutely wrong gesture that does not help the environment,” he added, saying work was under way to ensure there was no permanent damage.

The same group glued themselves to a plinth in the Vatican museums, to Sandro Botticelli’s “Primavera” masterpiece at the Uffizi galleries in Florence and to the Unique Forms of Continuity in Space statue at the Museo del Novecento in Milan last year.

They are also facing charges in Rome for throwing orange paint on the Italian Senate façade in January this year.

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Aliyah Boston forgoes 5th year at South Carolina, declares for WNBA draft

South Carolina Gamecocks superstar Aliyah Boston has made an important decision about her future.

In a social media post, the 2023 Naismith Defensive Player of the Year announced she will forgo her final year of eligibility and declare for the WNBA Draft

“God makes no mistakes this program has been so good to my family and I. Wouldn’t trade these past 4 years for anything. With love gamecock nation,” Boston wrote in a tweet Saturday.

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Aliyah Boston of the South Carolina Gamecocks reacts during the national championship trophy presentation after defeating the UConn Huskies 64-49 in the 2022 NCAA national championship game at Target Center April 3, 2022, in Minneapolis. 

Aliyah Boston of the South Carolina Gamecocks reacts during the national championship trophy presentation after defeating the UConn Huskies 64-49 in the 2022 NCAA national championship game at Target Center April 3, 2022, in Minneapolis.  (Andy Lyons/Getty Images)

She added that leaving South Carolina is the “next best decision” for her.

“In this moment, I am truly breathless as I make the next best decision of my life,” she wrote. “I have decided to further pursue my dream by declaring for the 2023 WNBA draft.”

Her decision comes after South Carolina’s undefeated season came to an end Friday night. Iowa star Caitlin Clark scored a record-breaking 41 points, leading the Hawkeyes to a 77-73 upset win in the Final Four.

Boston helped South Carolina win its second national title last season and is a three-time unanimous All-American.

GAMECOCKS COACH DAWN STALEY PUSHES BACK AT STYLE OF PLAY CRITICS FOLLOWING LOSS TO IOWA: ‘WE’RE NOT THUGS’

Boston won the Wooden Award in 2022 and was a finalist again this season. She’s widely expected to be the No. 1 pick in the draft April 10. The Indiana Fever hold the top pick.

Aliyah Boston (4) of the South Carolina Gamecocks shoots against the Iowa Hawkeyes during the semifinals of the NCAA Tournament Final Four at American Airlines Center March 31, 2023, in Dallas. 

Aliyah Boston (4) of the South Carolina Gamecocks shoots against the Iowa Hawkeyes during the semifinals of the NCAA Tournament Final Four at American Airlines Center March 31, 2023, in Dallas.  (Ben Solomon/NCAA Photos via Getty Images)

Boston had the option of staying with the Gamecocks a fifth season because her 2019-29 season was cut short by the COVID-19 pandemic.

She said she hadn’t yet decided about turning pro when reporters questioned her after the game against Iowa on Friday. But Boston made her decision with the blessing of head coach Dawn Staley.

South Carolina's Aliyah Boston holds up the championship trophy after defeating Tennessee 74-58 to win the championship game of the Southeastern Conference Tournament in Greenville, S.C., March 5, 2023.

South Carolina’s Aliyah Boston holds up the championship trophy after defeating Tennessee 74-58 to win the championship game of the Southeastern Conference Tournament in Greenville, S.C., March 5, 2023. (AP Photo/Mic Smith)

“I’m going to tell her to go,” Staley said Saturday. “There are defenses that are played against her that won’t allow her to play her game, and it’s hard to officiate that. So I would tell her to go. She’s great. She’s ready. She’s ready to see single coverage. She’s ready to make the next step to the league.”

Boston began playing for South Carolina in 2019. Two years prior to her joining the program, Staley led the Gamecocks to the first national title in the program’s history.

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Boston’s collegiate resume tells a story of dominance. She anchored the team for four seasons. South Carolina appeared in three consecutive Final Fours with Boston handling the starting center duties.

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1 dead, at least 28 injured after roof collapses at the Apollo Theatre in Illinois following dangerous storms



CNN
 — 

One person was killed and 28 others were injured after a full roof collapse at the Apollo Theatre in Belvidere, Illinois, on Friday evening following devastating storms and tornadoes that ripped through the South and Midwest, officials said.

Approximately 260 people, including guests, performers and staff, were inside the venue for a heavy metal rock concert at the time of the collapse, according to the event coordinator.

Belvidere is in northern Illinois, approximately 14 miles outside the city of Rockford. Despite severe weather in the region, there were no reports of an “actual tornado” hitting the area, Belvidere Fire Chief Shawn Schadle said.

In southern Illinois, three other people died in Crawford County after a residential structural collapse during Friday’s severe weather, according to Kevin Sur, a spokesperson for the Illinois Emergency Management Agency. The deaths confirmed in Illinois bring the overall death toll from Friday’s severe weather outbreak to 21 fatalities across six states.

At the Apollo Theatre, 28 people were transported by ambulance to nearby hospitals, Schadle said. Five had severe injuries; 18 had moderate injuries; and five had minor injuries. “Obviously there were probably other patients transported by personal vehicle,” he added.

During their initial response, crews coming into the building assisted in getting people out from under the debris. Crews established a triage center and relocation point for victims.

“It was a large response not only from all the public safety agencies, police, fire, as well as the bystanders to rescue those that were initially injured,” Schadle said.

A primary search of the theater has been completed, the chief said. “Right now, the MABAS 8 TRT rescue team is still operating behind us. They’re performing the secondary searches. They’re also looking into the stabilization of the building,” Schadle said.

Illinois Gov. JB Pritzker said he is “closely monitoring” the situation. “I’ve been in touch with officials for updates and to direct any available resources we can,” he said in a tweet Friday night. “As we learn more, please follow the guidance of all local authorities.”

Morbid Angel, one of the metal bands scheduled to perform at the event, issued a statement on Facebook canceling the concert and urging fans to “seek shelter and stay safe.”

“We are currently sheltering in place, and want to extend our support and hope that everyone at the show tonight is safe. Right now our focus is on making sure everyone in the venue tonight is ok and gets home,” the band said.

A flyer for the event shows other bands set to perform on Friday evening were Revocation, Skeletal Remains and Crypta.

An investigation into the collapse is ongoing. Schadle said no first responders were injured and so far everyone has been accounted for.

“The Illinois Emergency Management Agency is working closely with our local and county public safety partners and Emergency Managers to assess the widespread damages across the state including here at the Apollo Theatre in Belvidere in Boone County, and at Robinson in Crawford County,” the agency’s director, Alicia Tate-Nadeau, said in a statement. “We continue to assessing other damages in many counties across Illinois.”


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